The Relationship between Status at Presentation and Outcomes among Pregnant Women with COVID-19
Autor: | Fouad Atallah, Nelli Fisher, Howard Minkoff, Rodney McLaren, Sandra McCalla, Janet L. Stein, Viktoriya London, Shoshana Haberman, Catherine Cepeda |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Cohort Studies
0302 clinical medicine COVID-19 Testing Pregnancy Obstetrics and Gynaecology Medicine Infection control Pregnancy Complications Infectious 030219 obstetrics & reproductive medicine Obstetrics Pregnancy Outcome Obstetrics and Gynecology Gestational age lymphopenia Hospitalization Original Article Female Patient Safety medicine.symptom preterm delivery Coronavirus Infections Cohort study Adult medicine.medical_specialty Pneumonia Viral Gestational Age Asymptomatic Risk Assessment Statistics Nonparametric 03 medical and health sciences Humans Pediatrics Perinatology and Child Health Pandemics Asymptomatic Diseases Retrospective Studies Infection Control Chi-Square Distribution business.industry SARS-CoV-2 Clinical Laboratory Techniques COVID-19 Retrospective cohort study medicine.disease Infectious Disease Transmission Vertical Pediatrics Perinatology and Child Health vertical transmission New York City business Chi-squared distribution |
Zdroj: | American Journal of Perinatology |
ISSN: | 1098-8785 0735-1631 |
Popis: | Objective This study was aimed to compare maternal and pregnancy outcomes of symptomatic and asymptomatic pregnant women with novel coronavirus disease 2019 (COVID-19). Study Design This is a retrospective cohort study of pregnant women with COVID-19. Pregnant women were divided into two groups based on status at admission, symptomatic or asymptomatic. All testing was done by nasopharyngeal swab using polymerase chain reaction (PCR) for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Initially, nasopharyngeal testing was performed only on women with a positive screen (symptoms or exposure) but subsequently, testing was universally performed on all women admitted to labor and delivery. Chi-square and Wilcoxon's rank-sum tests were used to compare outcomes between groups. Results Eighty-one patients were tested because of a positive screen (symptoms [ n = 60] or exposure only [ n = 21]) and 75 patients were universally tested (all asymptomatic). In total, there were 46 symptomatic women and 22 asymptomatic women (tested based on exposure only [ n = 12] or as part of universal screening [ n = 10]) with confirmed COVID-19. Of symptomatic women ( n = 46), 27.3% had preterm delivery and 26.1% needed respiratory support while none of the asymptomatic women ( n = 22) had preterm delivery or need of respiratory support ( p = 0.007 and 0.01, respectively). Conclusion Pregnant women who presented with COVID19-related symptoms and subsequently tested positive for COVID-19 have a higher rate of preterm delivery and need for respiratory support than asymptomatic pregnant women. It is important to be particularly rigorous in caring for COVID-19 infected pregnant women who present with symptoms. Key Points Respiratory support is often needed for women who present with symptoms. Low rate of severe disease in women who present without symptoms. There were no neonatal infections on day 0 of life. |
Databáze: | OpenAIRE |
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