The Relationship between Status at Presentation and Outcomes among Pregnant Women with COVID-19

Autor: Fouad Atallah, Nelli Fisher, Howard Minkoff, Rodney McLaren, Sandra McCalla, Janet L. Stein, Viktoriya London, Shoshana Haberman, Catherine Cepeda
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Cohort Studies
0302 clinical medicine
COVID-19 Testing
Pregnancy
Obstetrics and Gynaecology
Medicine
Infection control
Pregnancy Complications
Infectious

030219 obstetrics & reproductive medicine
Obstetrics
Pregnancy Outcome
Obstetrics and Gynecology
Gestational age
lymphopenia
Hospitalization
Original Article
Female
Patient Safety
medicine.symptom
preterm delivery
Coronavirus Infections
Cohort study
Adult
medicine.medical_specialty
Pneumonia
Viral

Gestational Age
Asymptomatic
Risk Assessment
Statistics
Nonparametric

03 medical and health sciences
Humans
Pediatrics
Perinatology
and Child Health

Pandemics
Asymptomatic Diseases
Retrospective Studies
Infection Control
Chi-Square Distribution
business.industry
SARS-CoV-2
Clinical Laboratory Techniques
COVID-19
Retrospective cohort study
medicine.disease
Infectious Disease Transmission
Vertical

Pediatrics
Perinatology and Child Health

vertical transmission
New York City
business
Chi-squared distribution
Zdroj: American Journal of Perinatology
ISSN: 1098-8785
0735-1631
Popis: Objective This study was aimed to compare maternal and pregnancy outcomes of symptomatic and asymptomatic pregnant women with novel coronavirus disease 2019 (COVID-19). Study Design This is a retrospective cohort study of pregnant women with COVID-19. Pregnant women were divided into two groups based on status at admission, symptomatic or asymptomatic. All testing was done by nasopharyngeal swab using polymerase chain reaction (PCR) for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Initially, nasopharyngeal testing was performed only on women with a positive screen (symptoms or exposure) but subsequently, testing was universally performed on all women admitted to labor and delivery. Chi-square and Wilcoxon's rank-sum tests were used to compare outcomes between groups. Results Eighty-one patients were tested because of a positive screen (symptoms [ n = 60] or exposure only [ n = 21]) and 75 patients were universally tested (all asymptomatic). In total, there were 46 symptomatic women and 22 asymptomatic women (tested based on exposure only [ n = 12] or as part of universal screening [ n = 10]) with confirmed COVID-19. Of symptomatic women ( n = 46), 27.3% had preterm delivery and 26.1% needed respiratory support while none of the asymptomatic women ( n = 22) had preterm delivery or need of respiratory support ( p = 0.007 and 0.01, respectively). Conclusion Pregnant women who presented with COVID19-related symptoms and subsequently tested positive for COVID-19 have a higher rate of preterm delivery and need for respiratory support than asymptomatic pregnant women. It is important to be particularly rigorous in caring for COVID-19 infected pregnant women who present with symptoms. Key Points Respiratory support is often needed for women who present with symptoms. Low rate of severe disease in women who present without symptoms. There were no neonatal infections on day 0 of life.
Databáze: OpenAIRE