6-Methylsulfinylhexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice
| Autor: | Takanori Ikeda, Yuji Tanaka, Toshinori Kamisako, Hiroshi Ogawa, Shiori Masuda, Kazuo Yamamoto |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Iron Overload NF-E2-Related Factor 2 Physiology Hepatic iron accumulation Diet High-Fat Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Isothiocyanates Non-alcoholic Fatty Liver Disease Physiology (medical) Internal medicine medicine Animals Pharmacology Activator (genetics) Liver Diseases digestive oral and skin physiology Fatty liver nutritional and metabolic diseases food and beverages High fat diet medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology Liver chemistry Biochemistry 030220 oncology & carcinogenesis Isothiocyanate lipids (amino acids peptides and proteins) Steatosis hormones hormone substitutes and hormone antagonists 6-methylsulfinylhexyl isothiocyanate |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 43:1153-1156 |
| ISSN: | 0305-1870 |
| DOI: | 10.1111/1440-1681.12623 |
| Popis: | 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator. To determine whether 6-MSITC ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice were fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus 6-MSITC (10mg/Kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus 6-MSITC. The HFD increased hepatic triglycerides in both genotypes and 6-MSITC suppressed increased hepatic triglycerides in wild-type mice but did not reduce these triglycerides in Nrf2-null mice. Compared to the HFD and HFD/Iron groups, respectively, 6-MSITC did not block hepatic iron accumulation in either genotype. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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