Recognition and elimination of nonsense mRNA
| Autor: | Andrea B. Eberle, Rodolfo Zamudio Orozco, Oliver Mühlemann, Lukas Stalder |
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| Rok vydání: | 2008 |
| Předmět: |
Genetics
Regulation of gene expression Effector RNA Stability Nonsense-mediated decay Nonsense mutation Biophysics Biology Biochemistry mRNA surveillance Open reading frame Gene Expression Regulation Codon Nonsense Structural Biology P-bodies Animals Humans RNA Processing Post-Transcriptional Molecular Biology Gene |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779:538-549 |
| ISSN: | 1874-9399 |
| Popis: | Among the different cellular surveillance mechanisms in charge to prevent production of faulty gene products, nonsense-mediated mRNA decay (NMD) represents a translation-dependent posttranscriptional process that selectively recognizes and degrades mRNAs whose open reading frame (ORF) is truncated by a premature translation termination codon (PTC, also called "nonsense codon"). In doing so, NMD protects the cell from accumulating C-terminally truncated proteins with potentially deleterious functions. Transcriptome profiling of NMD-deficient yeast, Drosophila, and human cells revealed that 3-10% of all mRNA levels are regulated (directly or indirectly) by NMD, indicating an important role of NMD in gene regulation that extends beyond quality control [J. Rehwinkel, J. Raes, E. Izaurralde, Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors, Trends Biochem. Sci. 31 (2006) 639-646.[1]]. In this review, we focus on recent results from different model organisms that indicate an evolutionarily conserved mechanism for PTC identification. |
| Databáze: | OpenAIRE |
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