Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: Similar behavior to sporadic type?
| Autor: | María Correnti, Maira Ávila, Adriana Figueroa, Aleodor A. Andea, Patricia DeVilliers, Helen Rivera |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Nevoid basal-cell carcinoma syndrome Proliferating Cell Nuclear Antigen Oral and maxillofacial pathology Biomarkers Tumor medicine Humans Neoplasm Invasiveness biology business.industry Basal Cell Nevus Syndrome medicine.disease Immunohistochemistry Proliferating cell nuclear antigen stomatognathic diseases Cross-Sectional Studies Ki-67 Antigen Otorhinolaryngology Odontogenic Cysts biology.protein Surgery Keratocystic Odontogenic Tumor Tumor Suppressor Protein p53 business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 142:179-183 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1016/j.otohns.2009.10.008 |
| Popis: | The objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).We performed a cross-sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.Twelve cases corresponded to sporadic KCOT, and seven cases were associated with NBCCS. Immunohistochemical analysis for p53, proliferating cell nuclear antigen (PCNA), and Ki-67 was performed in all 19 cases.Of the seven cases associated with NBCCS, six (86%) were positive for PCNA. From the 12 sporadic cases, nine (75%) were positive for PCNA. Only one case of sporadic KCOT showed Ki-67 positivity. Five of 12 (42%) cases of sporadic KCOT were positive for p53, and only one (14%) case associated with NBCCS was positive for p53.On the basis of the analysis of the expression of PCNA, Ki-67, and p53, there appears to be no evidence to indicate higher aggressiveness in growth and infiltrative behavior in syndromic KCOT compared with the sporadic type. Therefore, surgical treatment may be approached in the same manner in KCOT sporadic and syndromic with the goal of minimizing recurrence. |
| Databáze: | OpenAIRE |
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