Estimating rock and slag wool fiber dissolution rate from composition
| Autor: | Walter Eastes, John G. Hadley, Russell M. Potter |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Materials science
Borosilicate glass Health Toxicology and Mutagenesis Oxide Mineralogy Toxicology Silicon Dioxide Ferric Compounds Silicate chemistry.chemical_compound chemistry Solubility visual_art visual_art.visual_art_medium Aluminum Oxide Animals Ceramic Fiber Glass Slag (welding) Composite material Mass fraction Dissolution |
| Zdroj: | Inhalation toxicology. 12(12) |
| ISSN: | 0895-8378 |
| Popis: | A method was tested for calculating the dissolution rate constant in the lung for a wide variety of synthetic vitreous silicate fibers from the oxide composition in weight percent. It is based upon expressing the logarithm of the dissolution rate as a linear function of the composition and using a different set of coefficients for different types of fibers. The method was applied to 29 fiber compositions including rock and slag fibers as well as refractory ceramic and special-purpose, thin E-glass fibers and borosilicate glass fibers for which in vivo measurements have been carried out. These fibers had dissolution rates that ranged over a factor of about 400, and the calculated dissolution rates agreed with the in vivo values typically within a factor of 4. The method presented here is similar to one developed previously for borosilicate glass fibers that was accurate to a factor of 1.25. The present coefficients work over a much broader range of composition than the borosilicate ones but with less accuracy. The dissolution rate constant of a fiber may be used to estimate whether disease would occur in animal inhalation or intraperitoneal injection studies of that fiber. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|