Myelodysplastic Syndrome Occurring in a Patient with Gorlin Syndrome
| Autor: | Susan J. Bayliss, Jamie L. Mull, Lisa M. Madden |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Bone marrow transplant medicine.medical_treatment Basal Cell Nevus Syndrome Dermatology 03 medical and health sciences Fatal Outcome 0302 clinical medicine hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Bone Marrow Transplantation African american Medulloblastoma Chemotherapy business.industry Myelodysplastic syndromes medicine.disease Surgery Patched-1 Receptor stomatognathic diseases PTCH1 Myelodysplastic Syndromes 030220 oncology & carcinogenesis Mutation Pediatrics Perinatology and Child Health Complication business 030217 neurology & neurosurgery |
| Zdroj: | Pediatric Dermatology. 33:e256-e257 |
| ISSN: | 0736-8046 |
| Popis: | We report a case of myelodysplastic syndrome (MDS) occurring in an African American boy with Gorlin syndrome with a novel PTCH1 mutation. Before developing MDS, the patient had been treated with chemotherapy and radiation for a medulloblastoma. He received a bone marrow transplant for the MDS and eventually died of treatment complications. Secondary hematologic malignancies are a known complication of certain chemotherapeutics, although whether a patient with Gorlin syndrome has a greater propensity for the development of such malignancies is unclear. |
| Databáze: | OpenAIRE |
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