Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine
| Autor: | Jae Kwang Song, Chaeyeon Lee, Taeheon Lee, Ji Eun Choi, Jeung Sang Go, Yung Doug Suh, Jun-O Jin, Li Xu, Hyun-jong Paik, Ji Hyun Park, Jonghwa Jeong, Wei Zhang, A.An Seong Soo, Sinae Jang, Hyeong Jin Jeon, Young-Sun Kang, Minseok Kwak, KyuHwan Shim, Chi-Yong Eom |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Polymers Influenza vaccine medicine.medical_treatment Biophysics Hemagglutinins Viral Nanoparticle Hemagglutinin (influenza) Bioengineering 02 engineering and technology Virus Biomaterials 03 medical and health sciences Influenza A Virus H1N1 Subtype Orthomyxoviridae Infections Antigen Biomimetic Materials In vivo medicine Animals Humans Particle Size Mice Inbred BALB C biology Chemistry Immunogenicity Dendritic Cells 021001 nanoscience & nanotechnology Virology Mice Inbred C57BL Hemagglutinins 030104 developmental biology Influenza Vaccines Mechanics of Materials Ceramics and Composites biology.protein Nanoparticles 0210 nano-technology Adjuvant Spleen |
| Zdroj: | Biomaterials. 183:234-242 |
| ISSN: | 0142-9612 |
| Popis: | The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutinin1 on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by in vivo studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect