Real-world use and acceptance of biosimilar monoclonal antibodies of rituximab in oncology practice in the USA
| Autor: | Ahmed Shelbaya, Jose Mj Alvir, Jingyan Yang, Martine C. Maculaitis, John M. Kelton, Jeffrey Thompson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty medicine.drug_class Chronic lymphocytic leukemia Monoclonal antibody 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Internal medicine medicine Retrospective analysis Humans 030212 general & internal medicine Biosimilar Pharmaceuticals Aged Retrospective Studies Adult patients business.industry Lymphoma Non-Hodgkin Biosimilar General Medicine Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Lymphoma Non-Hodgkin's lymphoma 030220 oncology & carcinogenesis Rituximab Female business medicine.drug |
| Zdroj: | Future oncology (London, England). 17(30) |
| ISSN: | 1744-8301 |
| Popis: | Aim: To describe treatment patterns and patient and provider characteristics associated with the recently introduced biosimilar rituximab-pvvr. Methods: This retrospective analysis included adult patients with one or more claims for rituximab-pvvr, with an index date of 23 January 2020 and a study period covering 1 January 2019–31 July 2020. Results: Of 249 patients included, the most common rituximab-pvvr indications were non-Hodgkin’s lymphoma (77.5%) and chronic lymphocytic leukemia (11.2%). Some patients with non-Hodgkin’s lymphoma (42.5%) and chronic lymphocytic leukemia (39.3%) switched to rituximab-pvvr from the reference product or another rituximab biosimilar. Most patients were aged ≥65 years (63.5%) and were male (54.6%). Most (59.0%) rituximab-pvvr prescribers practiced in the south of the USA. Conclusion: Utilization occurred in approved and extrapolated indications. These preliminary findings suggest switching between reference product and rituximab biosimilars; rituximab-pvvr combination regimens are being adopted in real-world oncology practice. |
| Databáze: | OpenAIRE |
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