Protective Effect of Xinmailong Injection on Rats With Myocardial Infarction
| Autor: | Kailiang Li, Quan-Jin Si, Wei Zhang, Yu Ding, Jiefeng Ren, Hai-Jun Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Physiology Sodium medicine.medical_treatment Intraperitoneal injection chemistry.chemical_element Hemodynamics Creatine Xinmailong injection lcsh:Physiology chemistry.chemical_compound Physiology (medical) Internal medicine Medicine Myocardial infarction Saline Original Research lcsh:QP1-981 business.industry rat model medicine.disease Phosphate myocardial injury marker Endocrinology myocardial infarction chemistry protective effect business |
| Zdroj: | Frontiers in Physiology, Vol 11 (2021) Frontiers in Physiology |
| ISSN: | 1664-042X |
| Popis: | This study aimed to investigate the protective effect of Xinmailong injection on rats with myocardial infarction. Thirty-six rats were induced myocardial infarction by operation, and six underwent sham operation. The myocardial infarction rats were randomly divided into three groups, 12 in each, and administered intraperitoneal injection of Xinmailong 5 mg/(kg·d), sodium creatine phosphate 80 mg/(kg·d), or normal saline as control respectively for 14 days. When the treatments were completed, the hemodynamic parameters of the rats were observed, and blood samples were taken to examine blood routine, blood coagulation index, liver and kidney function, inflammatory index, myocardial marker, thrombo-elastography, and other indicators. The morphology of cardiomyocytes was observed through light microscopy, and the microstructure of the myocardial cells was observed under electron microscope. No significant difference was found in blood routine, liver and kidney function, and blood coagulation index between the Xinmailong and sodium creatine phosphate groups compared with the saline control group. However, the inflammatory index and levels of myocardial markers were significantly decreased, and cardiac function was significantly improved. In terms of the morphology of myocardial cells, the Xinmailong group was similar to the sodium creatine phosphate group, the myocardial cell membrane was protected, and myocardial cell damage was reduced. In conclusion, Xinmailong is safe and had anti-inflammatory, heart-improving, and myocardial-protective effects. Its effectiveness is not inferior to that of sodium creatine phosphate. |
| Databáze: | OpenAIRE |
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