Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling
| Autor: | Lester Packer, Enrique Cadenas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
AMPK
Cell signaling insulin Clinical Biochemistry Cell Medicine (miscellaneous) Review Mitochondrion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dihydrolipoic acid PGC1α Medicine Transcription factor PI3K/AKT/mTOR pathway 030304 developmental biology 0303 health sciences Nutrition and Dietetics business.industry lipoic acid mitochondria Lipoic acid medicine.anatomical_structure chemistry Biochemistry redox lipids (amino acids peptides and proteins) business dihydrolipoic acid 030217 neurology & neurosurgery energy |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| Popis: | The role of R-α-lipoic acid as a cofactor (lipoyllysine) in mitochondrial energy metabolism is well established. Lipoic acid non-covalently bound and exogenously administered to cells or supplemented in the diet is a potent modulator of the cell’s redox status. The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide exchange reactions that modulate the environment’s redox and energy status. Lipoic acid-driven thiol/disulfide exchange reactions appear critical for the modulation of proteins involved in cell signaling and transcription factors. This review emphasizes the effects of lipoic acid on PI3K and AMPK signaling and related transcriptional pathways that are integrated by PGC-1α, a critical regulator of energy homoestasis. The effects of lipoic acid on the neuronal energy-redox axis are largely reviewed in terms of their outcomes for aging and age-related neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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