Increased Acute Phase Reactants are Associated with Levels of Lipoproteins and Increased Carotid Plaque Volume
| Autor: | H. Laursen, Britt M Wiebe, Henrik Sillesen, Marie-Louise M. Grønholdt, Børge G. Nordestgaard |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Pathology Arteriosclerosis medicine.medical_treatment Lipoproteins Orosomucoid Carotid endarterectomy chemistry.chemical_compound Predictive Value of Tests Risk Factors Internal medicine Image Processing Computer-Assisted Humans Medicine Carotid Stenosis Ultrasonics Ultrasonography Doppler Color Aged Endarterectomy Medicine(all) Carotid disease Analysis of Variance Endarterectomy Carotid Chi-Square Distribution biology business.industry Cholesterol C-reactive protein Echogenicity Middle Aged medicine.disease Acute phase reactants C-Reactive Protein Postprandial chemistry Area Under Curve Linear Models biology.protein Cardiology Female Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Vascular and Endovascular Surgery. (3):227-234 |
| ISSN: | 1078-5884 |
| DOI: | 10.1053/ejvs.2001.1321 |
| Popis: | Objectives to test the hypotheses that increased acute phase reactants predict elevated levels of lipoproteins and increased plaque volume as well as echolucency of carotid plaques. Materials and Methods the study included 258 patients with ≥50% carotid artery stenosis. Acute phase reactants (orosomucoid, C-reactive protein (CRP)) were measured in the fasting state, and ultracentrifugated lipoproteins before and after a standardised fat load test. Echogenicity of carotid plaques was detected using high-resolution B-mode ultrasound and computer-assisted image processing. A subgroup of 81 patients underwent carotid endarterectomy. Results on linear regression analysis orosomucoid levels were positively associated with fasting and postprandial levels of all triglyceride-rich lipoproteins, and negatively associated with HDL cholesterol (p -values |
| Databáze: | OpenAIRE |
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