The action of agonists and an antagonist of GABA on the frequency composition of the electrical activity of various brain structures of rats
| Autor: | V. V. Vorob'ev, A. V. Yarkov, Kovalev Gi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Baclofen Dorsal hippocampus Bicuculline GABA Antagonists chemistry.chemical_compound Internal medicine medicine Animals GABA-A Receptor Antagonists Rats Wistar gamma-Aminobutyric Acid Muscimol General Neuroscience Putamen Antagonist Brain Electroencephalography Receptors GABA-A Cortex (botany) Rats Endocrinology medicine.anatomical_structure nervous system chemistry Ventricle Neuroscience medicine.drug |
| Zdroj: | Neuroscience and behavioral physiology. 23(1) |
| ISSN: | 0097-0549 |
| Popis: | The frequency composition of the electrograms (EG) of the visual area of the cortex and deep brain structures (putamen, dorsal hippocampus, medial portion of the mid-hypothalamus) were investigated in chronic experiments in 36 awake rats under the conditions of the separate and combined introduction of GABA, its agonists (muscimol, baclofen), and an antagonist (bicuculline) into the lateral ventricle of the brain. The principal effects were manifested primarily in the form of a decrease in the power of the oscillations in the 7–16 Hz region of the range (1–25 Hz) of EG frequencies analyzed. Even though these changes were unidirectional following the administration of the agonists, they nevertheless differed with respect to the degree of expressivity in the different structures. Bicuculline, injected agaisnt the background of the action of muscimol and baclofen, attenuated the effects induced by them. The possible mechanisms of the phenomena discovered are discussed. |
| Databáze: | OpenAIRE |
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