Toll-like receptor 9 polymorphisms and Hepatitis B virus clearance in Moroccan chronic carriers

Autor: Hajar Chihab, Imane Zaidane, Abdellah Elhabazi, Fatima-Zahra Jadid, Raouia El Fihri, Mohcine Elmessaoudi-Idrissi, Mohammed Chair, Wafaa Badre, Mohamed Tahiri, Pascal Pineau, Isabelle Chemin, Sayeh Ezzikouri, Soumaya Benjelloun
Přispěvatelé: Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), Laboratoire de Biotechnologie, Biochimie et Nutrition, Faculté des Sciences d’El Jadida, Université Chouaib Doukkali (UCD), CHU Ibn Rochd [Casablanca], Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by research grant from the Actions Concertées Inter Pasteuriennes (ACIP 2014) and the Association de Lutte Contre le SIDA (ALCS, FASP 2016), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
Hepatitis B virus
Heterozygote
Carcinoma
Hepatocellular
Genotype
Single-nucleotide polymorphism
Biology
medicine.disease_cause
Polymorphism
Single Nucleotide
03 medical and health sciences
Liver disease
Hepatitis B
Chronic
0302 clinical medicine
Immune system
Genetics
medicine
Humans
Genetic Predisposition to Disease
Innate immune system
Liver Neoplasms
TLR9
virus diseases
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
General Medicine
Middle Aged
Viral Load
Prognosis
medicine.disease
digestive system diseases
3. Good health
Morocco
030104 developmental biology
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Toll-Like Receptor 9
030220 oncology & carcinogenesis
Immunology
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Female
Viral load
Biomarkers
Zdroj: Gene
Gene, Elsevier, 2019, 687, pp.212-218. ⟨10.1016/j.gene.2018.11.041⟩
Gene, 2019, 687, pp.212-218. ⟨10.1016/j.gene.2018.11.041⟩
ISSN: 0378-1119
1879-0038
Popis: Objectives Toll-like receptor 9 (TLR9) plays a crucial role in the innate immune response against viral infections. The failure of this system may result, in an attenuated immune response against HBV. Recent research has focused on the possibility of targeting the defects in TLR9 pathway as a novel approach for anti-HBV treatment. Our study aimed to assess the impact of both TLR9 rs5743836 and rs187084 polymorphisms on spontaneous HBV clearance in Moroccan chronic HBV carriers. Methods In this study, 239 individuals chronically infected with HBV (CHB) and 133 subjects who spontaneously resolved the infection (SRB) were genotyped using a Taqman allelic discrimination assay. Results/conclusion Remarkably, we observed a dosage effect of both SNPs on viral loads; with a significant increase of circulating HBV DNA within AA, AG to GG rs5743836 genotypes, whereas the inverse phenomenon was noticed within rs187084 genotypes. There were no consistent association between TLR9 polymorphisms and spontaneous clearance of HBV, however, a significant association was observed between rs187084 AA genotype and HBV progression to advanced liver disease. Further studies on larger populations might be necessary to understand the modulating effect of TLR9 polymorphisms on HBV loads that remain a viral factor of paramount importance to predict HCC development.
Databáze: OpenAIRE
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