Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis
| Autor: | Vera Esteves Vagnozzi Rullo, Renata Mota Carneiro, Dennis Alexander Burns, Wanderley Marques Bernardo, Felipe Toyama Aires, Fernando Pereira de Sá |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pediatrics
medicine.medical_specialty Home oxygen therapy MEDLINE law.invention Probiotic Enteral Nutrition Randomized controlled trial Enterocolitis Necrotizing law Sepsis Humans Infant Very Low Birth Weight Medicine Pediatrics Perinatology and Child Health Children Randomized Controlled Trials as Topic Enterocolitis Prematuros Neonatal sepsis business.industry Probiotics Incidence (epidemiology) Infant Newborn Probióticos lcsh:RJ1-570 lcsh:Pediatrics medicine.disease digestive system diseases Hospitalization Oxygen Enterocolite necrosante Meta-analysis Pediatrics Perinatology and Child Health Necrotizing enterocolitis medicine.symptom business Infant Premature |
| Zdroj: | Jornal de Pediatria, Vol 89, Iss 1, Pp 18-24 (2013) Jornal de Pediatria (Versão em Português), Vol 89, Iss 1, Pp 18-24 (2013) |
| ISSN: | 2255-5536 |
| DOI: | 10.1016/j.jpedp.2012.09.001 |
| Popis: | Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p |
| Databáze: | OpenAIRE |
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