| Autor: |
G E, Mark, R J, MacIntyre, M E, Digan, L, Ambrosio, N, Perrimon |
| Rok vydání: |
1987 |
| Předmět: |
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| Zdroj: |
Molecular and Cellular Biology. 7:2134-2140 |
| ISSN: |
1098-5549 |
| DOI: |
10.1128/mcb.7.6.2134-2140.1987 |
| Popis: |
A murine v-raf probe, representing the kinase domain, was used to identify two unique loci in Drosophila melanogaster DNA. The most closely related to v-raf was mapped by in situ hybridization to position 2F5-6 (Draf-1) on the X chromosome, whereas the other raf-related gene (Draf-2) was found at position 43A2-5 on chromosome 2. The nucleotide and amino acid homologies of Draf-1 to the kinase domain of v-raf are 61 and 65%, respectively. The large amount of a 3.2-kilobase Draf-1 transcript detected in eggs as a maternal message decreases during embryonic development, and significant steady-state levels are observed throughout the remainder of morphogenesis. We speculate that the Draf-1 locus plays an important role in early embryogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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