Inhalation of peptide-loaded nanoparticles improves heart failure
Autor: | Anna Tampieri, Pierluigi Carullo, Gianluigi Condorelli, Heiner Post, Lorenzo Degli Esposti, Nicolò Salvarani, Michele Iafisco, Tatiana Patrício, Silvana Pinelli, Marco Vacchiano, Stefano Rossi, Francesca Rossi, Daniele Catalucci, Gloria Belén Ramírez-Rodríguez, Alessio Alogna, Marco Erreni, Rossella Alinovi, Michele Miragoli, Paola Ceriotti, Francesca Ravanetti |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Calcium Phosphates
Male 0301 basic medicine Swine heart failure Peptide 02 engineering and technology Pharmacology Mice 03 medical and health sciences Text mining calcium phosphate nanoparticles therapeutic peptides cardiovascular disease Administration Inhalation myocardium medicine Animals Rats Wistar chemistry.chemical_classification Drug Carriers inhalation Inhalation business.industry nanoparticle General Medicine 021001 nanoscience & nanotechnology Highly selective medicine.disease drug-delivery Rats 3. Good health Mice Inbred C57BL 030104 developmental biology chemistry Echocardiography Heart failure drug delivery Nanoparticles Peptides 0210 nano-technology business |
Zdroj: | Science translational medicine 10 (2018). doi:10.1126/scitranslmed.aan6205 info:cnr-pdr/source/autori:Michele Miragoli, Paola Ceriotti, Michele Iafisco, Marco Vacchiano, Nicolò Salvarani, Alessio Alogna, Pierluigi Carullo, Gloria Belén Ramirez-Rodríguez, Tatiana Patrício, Lorenzo Degli Esposti, Francesca Rossi, Francesca Ravanetti, Silvana Pinelli, Rossella Alinovi, Marco Erreni, Stefano Rossi, Gianluigi Condorelli, Heiner Post, Anna Tampieri, Daniele Catalucci/titolo:Inhalation of peptide-loaded nanoparticles improves heart failure/doi:10.1126%2Fscitranslmed.aan6205/rivista:Science translational medicine/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:10 Science Translational Medicine |
DOI: | 10.1126/scitranslmed.aan6205 |
Popis: | Peptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small ( |
Databáze: | OpenAIRE |
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