Effect of acute metabolic acid/base shifts on the human airway calibre

Autor: Frank J.J. van den Elshout, F. Brijker, Hans Th.M. Folgering, F. H. Bosch, Yvonne F. Heijdra
Rok vydání: 2001
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Alkalosis
Physiology
Specific Airway Conductance
Metabolic alkalosis
mogelijke oorzaken en gevolgen (sepsis en ontsteking) [Sepsis en niet-bacteriële gegeneraliseerde ontsteking]
Acid–base homeostasis
causes and effects (sepsis and inflammation) [Sepsis and non-bacterial generalized inflammation]
Ammonium Chloride
Bronchoconstrictor Agents
Random Allocation
Airway resistance
Double-Blind Method
Forced Expiratory Volume
Internal medicine
medicine
Humans
Control mechanisms in asthma and chronic obstructive pulmonary disease
Respiratory system
Muscle
Skeletal
Lung
Acidosis
Hand Strength
business.industry
Airway Resistance
Hydrogen-Ion Concentration
Middle Aged
medicine.disease
Bronchodilator Agents
Sodium Bicarbonate
Endocrinology
Anesthesia
Regulatie mechanismen bij astma en chronisch obstructieve longaandoeningen
Female
Base excess
Blood Gas Analysis
medicine.symptom
Pulmonary Ventilation
business
Histamine
Zdroj: Respiration Physiology, 124, 151--8
Respiration Physiology, 124, 2, pp. 151--8
ISSN: 0034-5687
DOI: 10.1016/S0034-5687(00)00196-1
Popis: Item does not contain fulltext Acute metabolic alkalosis (NaHCO(3)), acidosis (NH(4)Cl), and placebo (NaCl) were induced in 15 healthy volunteers (12 females, median age 34 (range 24-56) years) in a double blind, placebo controlled study to evaluate the presence of the effects on airway calibre. Acid-base shifts were determined by capillary blood gas sampling. Measurements were performed at the maximal acid-base shift, 90 min after intervention. Airway resistance (R(aw)) and specific airway conductance (sG(aw)), were evaluated, as primary variables, pre and post intervention. Secondary variables, including bronchial responsiveness to histamine, maximal respiratory mouth pressures and grip strength, were evaluated post intervention. In alkalosis, base excess (BE) increased from -0.3 (-3.0-1.9) to 3.0 (1.0-4.8) mmol/l and pH increased from 7.41 (7.37-7.43) to 7.44 (7.39-7.47) (both P
Databáze: OpenAIRE
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