Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
| Autor: | Nitin Jagtap, Rakesh Kalapala, D. Nageshwar Reddy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gastroparesis
Manometry business.industry Gastroenterology Pyloric sphincter Pylorus Balloon medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Interquartile range 030220 oncology & carcinogenesis Healthy volunteers medicine Original Article 030211 gastroenterology & hepatology Neurology (clinical) Butyl bromide Nuclear medicine business Prospective cohort study |
| Zdroj: | Journal of Neurogastroenterology and Motility |
| ISSN: | 2093-0887 2093-0879 |
| DOI: | 10.5056/jnm19200 |
| Popis: | Background/Aims The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus using EndoFLIP to create normative data. Methods We performed a prospective study of 20 healthy volunteers (ages, 18-54 years; 10 men) who underwent pylorus evaluation using 12- cm FLIP placed across the pyloric sphincter. FLIP data were analyzed using FLIP planimetry plots at baseline and after administration of hyoscine butyl bromide injection. Results The median pylorus distensibility index (P-DI) was 8.37 mm2/mmHg (interquartile range, 4.22-13.04 mm2/mmHg) at 40 mL balloon volume. The 90th percentile at 40 mL balloon for P-DI was 14.89 mm2/mmHg, for cross-sectional area was 244.20 mm2/mmHg, and diameter and pressure were 17.58 mm and 48.84 mmHg, respectively. There was significant increase in P-DI after administration of hyoscine butyl bromide injection (P < 0.05). Conclusion The normative values can be used as reference values for pyloric distensibility. This reference can be used in studies of related to pyloric diseases such as gastroparesis. |
| Databáze: | OpenAIRE |
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