Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice
| Autor: | Barry J. Hoffer, Lars Olson, Kai Yun Chen, Yen Hua Chen, Alvin T. S. Brodin, Jing Huei Lai, John Chung Che Wu, Chi Zong Huang, Yung Hsiao Chiang, Shuo Jhen Kang, Tobias Karlsson |
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| Rok vydání: | 2019 |
| Předmět: |
Male
030506 rehabilitation Traumatic brain injury Emotions Mice Transgenic Mice 03 medical and health sciences Cognition Prosencephalon 0302 clinical medicine Nogo Receptor 1 mental disorders Animals Medicine Postural Balance Brain Concussion Spatial Memory Balance (ability) Neurons business.industry Recovery of Function medicine.disease Disease Models Animal Female Neurology (clinical) 0305 other medical science business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 36:1054-1059 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2018.5949 |
| Popis: | Mild traumatic brain injury (mTBI) constitutes 75 ∼ 90% of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here, we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory, and emotion. We compared wild-type (WT), MemoFlex, and MemoFlex + doxycycline mice to the same three groups subjected to mTBI. mTBI was induced by a controlled 30-g weight drop. We found that inability to downregulate NgR1 significantly impairs recovery from mTBI-induced impairments. When the NgR1 transgene was turned off, recovery was similar to that of WT mice. The results suggest that the ability to regulate NgR1 signaling is needed for optimal recovery of motor coordination and balance, spatial memory, cognition, and emotional functions after mTBI. |
| Databáze: | OpenAIRE |
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