Role of Patient Sex in Early Recovery from Alcohol-Related Cognitive Impairment: Women Penalized
| Autor: | Hélène Donnadieu-Rigole, Stéphanie Pelletier, Régis Alarcon, Bertrand Nalpas, Amandine Luquiens, Pascal Perney, Amine Benyamina, Benjamin Rolland |
|---|---|
| Přispěvatelé: | roussel, pascale, Hôpital Paul Brousse, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier le Vinatier [Bron], Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Universitaire de Réadaptation, de Rééducation et d'Addictologie du CHU de Nîmes [Grau-du-Roi] (CHU Nîmes), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Université de Montpellier (UM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject [SDV]Life Sciences [q-bio] lcsh:Medicine Alcohol use disorder Logistic regression Article 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine gender 030212 general & internal medicine 10. No inequality media_common cognitive impairment business.industry Addiction lcsh:R alcohol-use disorder Montreal Cognitive Assessment Cognition General Medicine Odds ratio Abstinence medicine.disease cognitive recovery cognitive remediation MOCA [SDV] Life Sciences [q-bio] Cognitive remediation therapy business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, 2019, 8 (6), pp.790. ⟨10.3390/jcm8060790⟩ Journal of Clinical Medicine, MDPI, 2019, 8 (6), pp.790. ⟨10.3390/jcm8060790⟩ Journal of Clinical Medicine, Vol 8, Iss 6, p 790 (2019) Journal of Clinical Medicine; Volume 8; Issue 6; Pages: 790 |
| ISSN: | 2077-0383 |
| Popis: | International audience; Background: The objective was to explore the role of patient sex in cognitive recovery and to identify predictive factors for non-recovery in alcohol use disorder (AUD). Methods: All patients with AUD admitted to a residential addictions treatment center were systematically assessed at admission and after 6 weeks of abstinence in a controlled environment. The inclusion criteria were that patients were admitted for AUD with baseline alcohol-related cognitive impairment (baseline total Montreal Cognitive Assessment (MoCA) score \textless 26) and reassessed at 6 weeks (n = 395). A logistic regression model was built to determine the influence of sex on recovery status (MoCA \textless or >= 26) taking into account the interaction effect of sex with alcohol consumption on cognitive function. Results: The mean age was 50.10 years (SD = 9.79), and 27.41% were women. At baseline, the mean MoCA scores were 21.36 (SD = 3.04). Participants who did not achieve recovery (59.3% of women vs 53.8% of men) had lower total MoCA scores at baseline. The 2 factors that was significantly and independently associated with non-recovery and with a non-zero coefficient was being a woman and initial MoCA score (respective adjusted odds ratios (AOR) = 1.5 and 0.96, p-values \textless 0.05). Conclusions: These results could influence the time required in a controlled environment to maintain abstinence and the duration of in-care for women. |
| Databáze: | OpenAIRE |
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