A kit-based aluminium-[ 18 F]fluoride approach to radiolabelled microbubbles
| Autor: | Nicholas J. Long, Jin Hui Teh, Chris P. Barnes, Louis Allott, Javier Hernández-Gil, Meng-Xing Tang, Eric O. Aboagye, Marta Braga |
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| Jazyk: | angličtina |
| Předmět: |
Chemistry
Radiochemistry Metals and Alloys chemistry.chemical_element General Chemistry Conjugated system Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Tetrazine chemistry.chemical_compound Aluminium Yield (chemistry) Materials Chemistry Ceramics and Composites Microbubbles 18f fluoride Fluoride |
| Zdroj: | Chemical Communications |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d1cc04790f |
| Popis: | The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) 'click' chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting. |
| Databáze: | OpenAIRE |
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