Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals
| Autor: | Sarah A. Cooley, Tammie L.S. Benzinger, Helen Beaumont, John Doyle, Beau M. Ances, Anna H. Boerwinkle, Jeremy F. Strain, John C. Morris |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty AIDS Dementia Complex Human immunodeficiency virus (HIV) HIV Infections Standardized uptake value medicine.disease_cause Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Hiv infected Internal medicine mental disorders medicine Humans Immunology and Allergy Dementia Aged medicine.diagnostic_test business.industry Neurodegeneration virus diseases Middle Aged medicine.disease 030104 developmental biology Infectious Diseases Increased risk Positron emission tomography Positron-Emission Tomography Female Alzheimer's disease business 030217 neurology & neurosurgery |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)–negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4(+) T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration. |
| Databáze: | OpenAIRE |
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