LncRNA GAS5 contributes to lymphatic metastasis in colorectal cancer
| Autor: | Wenhong Deng, Yu Ding, Yongbin Zheng, Shilun Tong, Kuang Xiao, Cao Yang, Dan Song |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology Colorectal cancer Bioinformatics medicine.disease_cause Metastasis 0302 clinical medicine Gene Frequency Risk Factors GAS5 Genotype Odds Ratio Medicine Middle Aged Prognosis Phenotype Lymphatic Metastasis 030220 oncology & carcinogenesis Female RNA Long Noncoding Colorectal Neoplasms Research Paper China medicine.medical_specialty Tumor suppressor gene colorectal cancer 03 medical and health sciences Asian People Internal medicine Biomarkers Tumor metastasis Humans Genetic Predisposition to Disease Allele Genetic Association Studies Chi-Square Distribution business.industry Cancer Protective Factors medicine.disease LncRNA Logistic Models 030104 developmental biology Case-Control Studies Multivariate Analysis business Carcinogenesis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 1452-0427 |
| DOI: | 10.18632/oncotarget.13384 |
| Popis: | // Yongbin Zheng 1 , Dan Song 1 , Kuang Xiao 1 , Cao Yang 1 , Yu Ding 1 , Wenhong Deng 1 , Shilun Tong 1 1 Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China Correspondence to: Yongbin Zheng, email: zhengyongbinhb@163.com Keywords: colorectal cancer, GAS5, metastasis, LncRNA Received: August 17, 2016 Accepted: October 19, 2016 Published: November 16, 2016 ABSTRACT Colorectal cancer (CRC) ranks the third most common type of cancer worldwide. However, the detailed molecular mechanisms underlying these processes are poorly understood. Recent studies have shown that lncRNAs play important roles in carcinogenesis and progression of CRC. The lncRNA growth arrest special 5 (GAS5), was previously identified to be down-regulated and functions as a tumor suppressor gene in many kinds of cancers. In current two-stage, case-control study, we systematically evaluated the potential role of lncRNA GAS5 and its genetic variation rs145204276 in the development and metastasis process of CRC in a Chinese population. We found the allele del of rs145204276 was significantly associated with 21% decreased risk of CRC (OR=0.79; 95% CI=0.70-0.89; P value = 5.21×10 -5 ). Compared with the genotype ins/ins, both the genotype ins/del (OR=0.78; 95% CI=0.68-0.91) and del/del (OR=0.64; 95% CI=0.49-0.84) showed decreased susceptibility. For both in colon and rectum cancers, the associations kept statistically significant (OR=O.78 and 0.80, while P value = 4.56×10 -4 , and 3.80×10 -3 , respectively). The results also showed that the carriers of allele del are less likely to get lymph node metastasis (OR=0.80; 95% CI=0.68-0.95; P value = 0.010). Taken together, our findings provided strong evidence for the hypothesis that GAS5 rs145204276 were significantly associated with the susceptibility and progression of CRC. |
| Databáze: | OpenAIRE |
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