Selective activation of D1 dopamine receptors exerts antidepressant-like activity in rats
| Autor: | F. Lavergne, Fanny Demars, Thérèse M. Jay, Cleo Desormeaux, Elisabeth Davenas |
|---|---|
| Přispěvatelé: | Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Martinez Rico, Clara |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Dopamine [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Social Interaction Adamantane forced swim test (FST) Pharmacology Antidepressant like Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Animals Benzopyrans Pharmacology (medical) [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] 030304 developmental biology 0303 health sciences antidepressant Behavior Animal business.industry Receptors Dopamine D1 medicine.disease Antidepressive Agents Rats Psychiatry and Mental health Dopamine receptor D1-agonist [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Dopamine Agonists Major depressive disorder Antidepressant social interactions [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] business Psychosocial Locomotion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology Journal of Psychopharmacology, SAGE Publications, 2020, 34 (12), pp.1443-1448. ⟨10.1177/0269881120959613⟩ |
| ISSN: | 0269-8811 1461-7285 |
| DOI: | 10.1177/0269881120959613⟩ |
| Popis: | Background: Major depressive disorder is a common illness that severely decreases psychosocial functioning. Due to the major limitations of current treatments including response failure, it is crucial to develop better therapy strategies. Evidence suggests that dopamine dysregulation might play a major role in major depressive disorder physiopathology. Aims: This study investigates whether the dopamine D1 receptor agonist A77636 modulates antidepressant-like activity in rats. Methods: Rats were injected with an acute single dose of A77636 (0.75, 1.5 or 3 mg/kg), a potent and selective dopamine D1-like receptor agonist. Their locomotor activity, social interactions and behavioural response to the forced swim test were analysed 30 min after the injection. Results: During the forced swim test, the D1 agonist dose dependently reduced the immobility while the time of bursting was increased. Social interactions were significantly increased in the animals exposed to 3 mg/kg of A77636 whereas no significant changes were measured in general motor activity. Conclusions: The present results provide evidence that pharmacological modulation of D1 receptor by the selective agonist A77636 induces antidepressant-like effects in rats, which encourages further studies regarding D1-specific modulation in major depressive disorder treatment. |
| Databáze: | OpenAIRE |
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