Relation of Apolipoprotein E Polymorphism to Lipid Metabolism in Obese Children
| Autor: | G. Thomas, G. Bereziat, J. P. Girardet, G. Parlier, J. L. Fontaine |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Adolescent Genotype Lipoproteins Hyperlipidemias Biology Polymerase Chain Reaction Apolipoproteins E Polymorphism (computer science) Internal medicine medicine Humans Obesity Age of Onset Allele Child Alleles Triglycerides Polymorphism Genetic Apolipoprotein A-I Cholesterol HDL Hypertriglyceridemia Cholesterol LDL medicine.disease Lipids Cholesterol Phenotype Endocrinology Child Preschool Pediatrics Perinatology and Child Health Female lipids (amino acids peptides and proteins) Dyslipidemia Lipoprotein |
| Zdroj: | Pediatric Research. 41:682-685 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199705000-00013 |
| Popis: | To determine whether the risk of obesity-associated dyslipidemia in children is influenced by apolipoprotein E (apoE) polymorphism, we studied 137 obese, nongenetically related children aged 2.2-14.4 y (mean age, 9.9 +/- 3.1 y) with a weight-for-height excess of 43.7 +/- 17.9%. The apoE genotype was determined by studying specific DNA restriction patterns. Total cholesterol, HDL-cholesterol, and triglycerides were assayed in plasma before dietary treatment initiation. ApoE allele and phenotype distributions were comparable to those reported in the Caucasian population at large. Fifty-five children (41%) had elevated lipid levels. Compared with obese children with the epsilon3 or epsilon4 allele, those with the epsilon2 allele were more likely to have hypertriglyceridemia (19.5% versus 52.9%, p0.05) and had a higher mean triglyceride level: children with the epsilon4 allele were more likely to have a LDL-cholesterol elevation (34.7% versus 13.4%, p0.05). Our data demonstrate that, even in childhood, obesity is associated with a marked increase in the risk of lipoprotein abnormalities and that the latter are influenced by apoE polymorphism. |
| Databáze: | OpenAIRE |
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