Effects of Charcoal on Carbonyl Delivery from Commercial, Research, and Make-Your-Own Cigarettes
Autor: | Zachary T. Bitzer, Ryan J. Elias, Samantha M. Reilly, John P. Richie, Joshua E. Muscat, Neil Trushin, Reema Goel |
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Rok vydání: | 2018 |
Předmět: |
inorganic chemicals
Aldehydes Chromatography Chemistry food and beverages General Medicine Ketones respiratory system equipment and supplies Toxicology Cellulose acetate Article Phenylhydrazines carbohydrates (lipids) chemistry.chemical_compound Charcoal Smoke visual_art Tobacco visual_art.visual_art_medium Spectrophotometry Ultraviolet Sidestream smoke Derivatization Chromatography High Pressure Liquid |
Zdroj: | Chem Res Toxicol |
ISSN: | 1520-5010 0893-228X |
Popis: | Previous literature has shown that adding charcoal to cigarette filters can have varying effects on the delivery of toxic carbonyls depending on filter design, amount of charcoal, and puffing profiles. However, these studies have relied on either comparisons between commercially available charcoal and noncharcoal filtered cigarettes or experimental modification of filters to insert a charcoal plug into existing cellulose acetate filters. Make-your-own (MYO) cigarettes can help obviate many of the potential pitfalls of previous studies; thus, we conducted studies using commercial charcoal cigarettes and MYO cigarettes to determine the effects of charcoal on carbonyl delivery. To do this, we analyzed carbonyls in mainstream smoke by HPLC-UV after derivatization with 2,4-dinitrophenylhydrazine (DNPH). Charcoal was added in-line after the cigarettes or through the use of MYO charcoal cigarette tubes. MYO cigarettes had carbonyl deliveries similar to that of 3R4F research cigarette, regardless of tobacco type. The greatest effect on carbonyl delivery was observed with 200 mg of charcoal, significantly reducing all carbonyls under both methods tested. However, "on-tow" design charcoal filters, available on many commercially available charcoal brands, appeared to have a minimal effect on carbonyl delivery under intense smoking methods. Overall, we found that charcoal, when added in sufficient quantity (200 mg) as a plug, can substantially reduce carbonyl delivery for both MYO and conventional cigarettes. As carbonyls are related to negative health outcomes, such reductions may be associated with reductions in carbonyl-related harm in smokers. |
Databáze: | OpenAIRE |
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