The syntheses, characterization, antimicrobial, DNA cleavage and cytotoxic activities of novel terephthalato complexes
| Autor: | Murat Yılmaz, Emel Topaloğlu, Özge Yıldız, Pinar Oztopcu-Vatan, Tuba İça, Alper Tolga Çolak, Ferdağ Çolak |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Cytotoxicity Antimicrobial activity 010402 general chemistry 01 natural sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound Prostate carcinoma DU145 MTT assay Spectroscopy Terephthalic acid Nuclease DNA cleavage biology 010405 organic chemistry Organic Chemistry Antimicrobial 0104 chemical sciences chemistry Apoptosis Agarose gel electrophoresis biology.protein Terephthalate complexes Nuclear chemistry |
| Popis: | [Cu(tp)(dmpd) 2 ] (1) , [Cu(tp)(pen) 2 ] (2) , [Cu(tp)(dmen) 2 ] (3) , [Cu(tp)(deen) 2 ]·4H 2 O (4) , [Cu(tp)(mpen) 2 ]·2H 2 O (5) and [Cu(tp)(amp) 2 ]·3H 2 O (6) (H 2 tp = Benzene-1,4-dicarboxylic acid or terephthalic acid, dmpd = 2,2-dimethyl-1,3-propanediamine, pen = 1,3-propanediamine, dmen = N , N -dimethylethylenediamine, deen = N , N -diethylethylenediamine, mpen = N -methyl-1,3-propanediamine and amp = 2-aminomethylpyridine) were synthesised and characterised by elemental analysis, spectroscopic measurements (UV–vis. and FT-IR spectra) and thermal analysis technique. These complexes have been screened for antimicrobial activities and DNA cleavage. Antimicrobial activity of compounds 1 – 6 were evaluated by the agar diffusion method. The DNA cleavage activities of the complexes were evaluated by agarose gel electrophoresis. In addition, cytotoxic activities of all complexes were performed prostate carcinoma cells LNCaP and DU145 by MTT assay for 24 and 48 h. Especially after 24 h treatment, 6 complex increased the apoptotic and necrotic cell death in both cell lines in a concentration dependent manner. Particularly, 6 complex good show antimicrobial, nuclease and cytotoxic activity. |
| Databáze: | OpenAIRE |
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