Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
| Autor: | Paul V. Tan, Amang André Perfusion, Nyasse Barthelemy, Nkwengoua Ernestine |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Carbachol Article Subject medicine.drug_class Pharmacology chemistry.chemical_compound Internal medicine medicine Anticholinergic Pharmacology (medical) Secretion General Pharmacology Toxicology and Pharmaceutics business.industry digestive oral and skin physiology lcsh:RM1-950 Histaminergic Endocrinology lcsh:Therapeutics. Pharmacology chemistry Mechanism of action Molecular Medicine Gastric acid Cholinergic medicine.symptom business Histamine Research Article medicine.drug |
| Zdroj: | Advances in Pharmacological Sciences, Vol 2014 (2014) Advances in Pharmacological Sciences |
| ISSN: | 1687-6342 1687-6334 |
| Popis: | Objective.The objective of this study was to find out the possible antiulcer mechanism of action ofEremomastax speciosa.Method.Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric mucosal ulceration, mucus production, pH, gastric volume, and acidity were measured.Results.Histamine and carbachol raised gastric acidity to 86.50 and 84.80 mEq/L, respectively, in the control rats, and the extracts (200 mg/kg) reduced gastric acidity to 34.60 and 39.00 mEq/L, respectively. Intraduodenal aqueous extract (400 mg/kg) in histamine- and carbachol-treated rats produced significant (P<0.001) decreases in acid secretion to 28.50 and 28.80 mEq/L, respectively, and 100 percent inhibition of gastric ulceration. Augmented histamine-induced gastric acid secretion (90.20 mEq/L) was significantly reduced to 52.60 and 27.50 mEq/L by the 200 and 400 mg/kg doses of the aqueous extract, respectively. The extract significantly reduced (P<0.001) the volume of gastric secretion and significantly increased mucus production. The ulcer inhibition potential of the extract significantly dropped to 25–44% (oral extract) and to 29–37% (duodenal extract) in carbachol/indomethacin-treated rats.Conclusion.The aqueous extract ofE. speciosahas both cytoprotective and antisecretory effects. The antisecretory effect may involve a mechanism common to both cholinergic and histaminergic pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|