Comparison of the Fenwal Amicus and Fresenius Com.Tec cell separators for autologous peripheral blood progenitor cell collection
| Autor: | Mustafa Cetin, Fevzi Altuntaş, Leylagül Kaynar, Mehmet Oztekin, Ahmet Öztürk, Musa Solmaz, Bulent Eser, Ali Ünal, Ismail Sari, Ismail Kocyigit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment education Cell Urology CD34 apheresis Hematopoietic stem cell transplantation Transplantation Autologous Blood cell medicine Humans Autologous transplantation Leukapheresis Progenitor cell Erythroid Precursor Cells business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged Hodgkin Disease Hematopoietic Stem Cell Mobilization humanities Surgery Transplantation medicine.anatomical_structure Apheresis Blood Component Removal Female Multiple Myeloma business cell separators peripheral blood progenitor cells autologous |
| DOI: | 10.1016/j.transci.2006.10.008 |
| Popis: | Peripheral blood progenitor cells (PBPC) are commonly used as a stein cell source for autologous transplantation. This study was undertaken to evaluate blood cell separators with respect to separation results and content of the harvest. Forty autologous PBPC collections in patients with hernatological malignancies were performed with either the Amicus or the COM.TEC cell separators. The median product volume was lower with the Amicus compared to the COM.TEC (125 mL vs. 300 mL; p < 0.001). There was no statistically significant difference in the median number of CD34+ cell/ kg in product between the Amicus and the COM.TEC (3.0 x 10(6) vs. 4.1 X 10(6); P = 0.129). There was a statistically higher mean volume of ACD used in collections on the Amicus compared to the COM.TEC (1040 241 mL vs. 868 + 176 mL; p = 0.019). There was a statistical difference in platelet (PLT) contamination of the products between the Amicus and the COM.TEC (0.3 x 10(11) vs. 1.1 x 10(11); p < 0.001). The median % decrease in PB PLT count was statistically higher in the COM.TEC compared to the Amicus instruments (18.5% vs. 9.50/0; p = 0.028). In conclusion, both instruments collected PBPCs efficiently. However, Amicus has the advantage of lower PLT contamination in the product, and less decrease in PB platelet count with lower product volume in autologous setting. (c) 2007 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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