Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment
| Autor: | Norimitsu Tanaka, Shinichiro Hashiguchi, Motohiro Morioka, Kiyohiko Sakata, Hisashi Migita, Kiminobu Sato, T. Kurita, Takeharu Ono, Hirohito Umeno, Nobuyuki Takeshige, Kensuke Kiyokawa |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Surgical margin Maxillary sinus medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Recurrence medicine Humans Recurrent tumour Retrospective Studies Salvage Therapy Cisplatin business.industry Margins of Excision 030206 dentistry Surgery Radiation therapy medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Concomitant Carcinoma Squamous Cell Salvage surgery Neoplasm Recurrence Local Oral Surgery Positive Surgical Margin business medicine.drug |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 48:567-575 |
| ISSN: | 0901-5027 |
| DOI: | 10.1016/j.ijom.2018.10.019 |
| Popis: | Limited information about salvage surgery is available for locally persistent and recurrent maxillary sinus cancers after the completion of chemoradiation therapy. Seventy-six maxillary sinus cancer patients who had undergone chemoradioselection using initial radiotherapy and concomitant intra-arterial cisplatin were screened retrospectively. Twenty-four of these patients who had a locally persistent or recurrent tumour were investigated. The 2-year overall survival rate of patients with maxillary sinus cancer of all types was 39.0% for those who underwent salvage surgery and 10.0% for those who did not. The 2-year overall survival rate of patients with maxillary sinus squamous cell carcinoma was 45.8% for those who underwent salvage surgery and 11.1% for those who did not. Furthermore, the 2-year local control and overall survival rates of patients with positive and negative surgical margins were 14.3% and 83.3% and 14.3% and 66.7%, respectively. There were significant differences in local control (P=0.004) and overall survival (P=0.005) regarding surgical margin status. Although salvage surgery for a locally persistent or recurrent maxillary sinus cancer is a feasible treatment, patients with positive surgical margins are more prone to local relapse. Therefore, surgical safety margins should be assessed thoroughly. |
| Databáze: | OpenAIRE |
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