Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers
| Autor: | Kathleen Campbell, Eric Courchesne, Anders M. Dale, James A. Proudfoot, Donald J. Hagler, Cynthia Carter Barnes, Lisa T. Eyler, Clelia Ahrens-Barbeau, Stephanie Solso, Vijay K. Venkatraman, Karen Pierce, Ronghui Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Male genetic structures Autism Spectrum Disorder Autism Severity of Illness Index Medical and Health Sciences Corpus Callosum 0302 clinical medicine Neural Pathways Axon Child Psychiatry Brain Organ Size Biological Sciences White Matter Frontal Lobe medicine.anatomical_structure Diffusion Tensor Imaging Autism spectrum disorder DTI Child Preschool Tract volume Female Abnormality Psychology Fiber tract Development behavioral disciplines and activities Article Brain functioning 03 medical and health sciences Fractional anisotropy mental disorders medicine Humans Autistic Disorder Preschool Biological Psychiatry Psychology and Cognitive Sciences Infant Frontal tracts medicine.disease Axons 030104 developmental biology nervous system Anisotropy Tract FA Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Solso, S; Xu, R; Proudfoot, J; Hagler, DJ; Campbell, K; Venkatraman, V; et al.(2014). Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers. Biological Psychiatry. doi: 10.1016/j.biopsych.2015.06.029. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0gm9c0q1 Biological psychiatry, vol 79, iss 8 |
| Popis: | © 2015 Society of Biological Psychiatry. Background: Theories of brain abnormality in autism spectrum disorder (ASD) have focused on underconnectivity as an explanation for social, language, and behavioral deficits but are based mainly on studies of older autistic children and adults. Methods: In 94 ASD and typical toddlers ages 1 to 4 years, we examined the microstructure (indexed by fractional anisotropy) and volume of axon pathways using in vivo diffusion tensor imaging of fronto-frontal, fronto-temporal, fronto-striatal, and fronto-amygdala axon pathways, as well as posterior contrast tracts. Differences between ASD and typical toddlers in the nature of the relationship of age to these measures were tested. Results: Frontal tracts in ASD toddlers displayed abnormal age-related changes with greater fractional anisotropy and volume than normal at younger ages but an overall slower than typical apparent rate of continued development across the span of years. Posterior cortical contrast tracts had few significant abnormalities. Conclusions: Frontal fiber tracts displayed deviant early development and age-related changes that could underlie impaired brain functioning and impact social and communication behaviors in ASD. |
| Databáze: | OpenAIRE |
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