Investigation of IL-33 serum levels in patients with benign and malignant salivary gland tumors

Autor:	Razieh Zare, Mohamad Hashemi, Mahyar Malekzadeh, Bijan Khademi, Azadeh Andishe-Tadbir
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine Cancer Research medicine.medical_specialty Adenoma Pleomorphic Gastroenterology Pleomorphic adenoma 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine Biomarkers Tumor Genetics Carcinoma Humans Medicine In patient Aged Antibody-dependent cell-mediated cytotoxicity Mixed tumor Salivary gland business.industry General Medicine Middle Aged Interleukin-33 Salivary Gland Neoplasms medicine.disease Carcinoma Adenoid Cystic Interleukin 33 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Biomarker (medicine) Carcinoma Mucoepidermoid Female business
Zdroj:	Cancer Biomarkers. 23:61-65
ISSN:	1875-8592 1574-0153
DOI:	10.3233/cbm-181309
Popis:	BACKGROUND Interleukin-33 (IL-33) has been recently discovered as an influential factor in the process of tumor immunity, and is presented in cancer pathogenesis. OBJECTIVE This study aimed to determine the serum levels of IL-33 in patients with benign and malignant Salivary gland tumors (SGTs). METHODS This descriptive cross-sectional study was performed on 47 samples of malignant SGTs including 18 mucoepidermoid carcinoma (MEC), 8 adenoid cystic carcinoma (ADCC), 21 malignant mixed tumor (MMT), and 14 benign pleomorphic adenoma (PA). A control group was considered consisting of 28 healthy subjects. The serum level of IL-33 was measured by using sandwich ELISA method. The data were statistically analyzed through Kruskal-Wallis and Mann-Whitney tests. RESULTS The median concentration of IL-33 was 6.91 in malignant, 5.14 in benign, and 5.01 in healthy cases, with a statistically significant difference (P= 0.001). The median serum levels of IL-33 increased significantly in ADCC (7.15), MEC (7.03), and MMT (6.91) compared with the control group (5.01) (P< 0.05). The mean rank of MEC was significantly higher than PA (P= 0.01). IL-33 concentration was positively and significantly correlated with the tumor stage (P= 0.02) and tumor size (P= 0.03). CONCLUSIONS IL-33 could be suggested as a novel biomarker to distinguish different types of SGTs.
Databáze:	OpenAIRE
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