Heavy metals, welding fumes, and other occupational exposures, and the risk of kidney cancer: A population-based nested case-control study in three Nordic countries
Autor: | Johnni Hansen, Laufey Tryggvadottir, Jan Ivar Martinsen, Eero Pukkala, Pär Sparén, Elisabete Weiderpass, Irmina Maria Michalek |
---|---|
Přispěvatelé: | Department of Medical and Clinical Genetics, Faculty of Medicine |
Rok vydání: | 2019 |
Předmět: |
Occupational cancer
Iceland 010501 environmental sciences medicine.disease_cause 01 natural sciences Biochemistry 0302 clinical medicine RENAL-CELL CARCINOMA Medicine Welding 030212 general & internal medicine Finland General Environmental Science education.field_of_study CARCINOGENICITY 3142 Public health care science environmental and occupational health Kidney Neoplasms 3. Good health Heavy metals OBESITY Cohort Ultraviolet Rays NICKEL Population Job-exposure matrix Scandinavian and Nordic Countries Asbestos LEAD CADMIUM 03 medical and health sciences Metals Heavy Occupational Exposure Environmental health ASBESTOS Humans COHORT education METAANALYSIS 1172 Environmental sciences 0105 earth and related environmental sciences Exposure assessment Sweden business.industry MORTALITY Renal pelvis neoplasms medicine.disease Risk factors Case-Control Studies Nested case-control study business Kidney cancer |
Zdroj: | Environmental Research. 173:117-123 |
ISSN: | 0013-9351 |
Popis: | Objectives To determine whether occupational exposure to heavy metals (chromium (VI), iron, nickel, lead) and welding fumes is associated with the risk of kidney cancer and to describe whether other occupational exposures included in the Job Exposure Matrix of the Nordic Occupational Cancer (NOCCA) study are associated with the risk. Materials and methods Nested case-control study among individuals registered in population censuses in Finland, Iceland, and Sweden in 1960–1990. A total of 59,778 kidney cancer cases, and 298,890 controls matched on sex, age, and country. Cumulative occupational exposures to metals (chromium (VI), iron, nickel, lead), welding fumes, and 24 other occupational exposure covariates, lagged 0, 10, and 20 years. Results Overall, there was no or very little association between kidney cancer and exposures studied. The risk was elevated in individuals with high exposure to asbestos (OR 1.19, 95%CI 1.08–1.31). The risk was significantly decreased for individuals characterized with high perceived physical workload (OR 0.86, 95%CI 0.82–0.91), high exposure to ultraviolet radiation (OR 0.85, 95%CI 0.79–0.92), and high exposure to wood dust (OR 0.82, 95%CI 0.71–0.94). The risk of kidney cancer under the age of 59 was elevated in individuals with high exposure to nickel (OR 1.49, 95%CI 1.03–2.17). The risk of kidney cancer in age 59–74 years was elevated for individuals with high exposure to iron (OR 1.41, 95%CI 1.07–1.85), and high exposure to welding fumes (OR 1.43, 95%CI 1.09–1.89). Conclusions The only markedly elevated risks of kidney cancer were seen for the highest exposures of nickel and iron/welding fumes in specific age strata. |
Databáze: | OpenAIRE |
Externí odkaz: |