Heavy metals, welding fumes, and other occupational exposures, and the risk of kidney cancer: A population-based nested case-control study in three Nordic countries

Autor: Johnni Hansen, Laufey Tryggvadottir, Jan Ivar Martinsen, Eero Pukkala, Pär Sparén, Elisabete Weiderpass, Irmina Maria Michalek
Přispěvatelé: Department of Medical and Clinical Genetics, Faculty of Medicine
Rok vydání: 2019
Předmět:
Occupational cancer
Iceland
010501 environmental sciences
medicine.disease_cause
01 natural sciences
Biochemistry
0302 clinical medicine
RENAL-CELL CARCINOMA
Medicine
Welding
030212 general & internal medicine
Finland
General Environmental Science
education.field_of_study
CARCINOGENICITY
3142 Public health care science
environmental and occupational health
Kidney Neoplasms
3. Good health
Heavy metals
OBESITY
Cohort
Ultraviolet Rays
NICKEL
Population
Job-exposure matrix
Scandinavian and Nordic Countries
Asbestos
LEAD
CADMIUM
03 medical and health sciences
Metals
Heavy
Occupational Exposure
Environmental health
ASBESTOS
Humans
COHORT
education
METAANALYSIS
1172 Environmental sciences
0105 earth and related environmental sciences
Exposure assessment
Sweden
business.industry
MORTALITY
Renal pelvis neoplasms
medicine.disease
Risk factors
Case-Control Studies
Nested case-control study
business
Kidney cancer
Zdroj: Environmental Research. 173:117-123
ISSN: 0013-9351
Popis: Objectives To determine whether occupational exposure to heavy metals (chromium (VI), iron, nickel, lead) and welding fumes is associated with the risk of kidney cancer and to describe whether other occupational exposures included in the Job Exposure Matrix of the Nordic Occupational Cancer (NOCCA) study are associated with the risk. Materials and methods Nested case-control study among individuals registered in population censuses in Finland, Iceland, and Sweden in 1960–1990. A total of 59,778 kidney cancer cases, and 298,890 controls matched on sex, age, and country. Cumulative occupational exposures to metals (chromium (VI), iron, nickel, lead), welding fumes, and 24 other occupational exposure covariates, lagged 0, 10, and 20 years. Results Overall, there was no or very little association between kidney cancer and exposures studied. The risk was elevated in individuals with high exposure to asbestos (OR 1.19, 95%CI 1.08–1.31). The risk was significantly decreased for individuals characterized with high perceived physical workload (OR 0.86, 95%CI 0.82–0.91), high exposure to ultraviolet radiation (OR 0.85, 95%CI 0.79–0.92), and high exposure to wood dust (OR 0.82, 95%CI 0.71–0.94). The risk of kidney cancer under the age of 59 was elevated in individuals with high exposure to nickel (OR 1.49, 95%CI 1.03–2.17). The risk of kidney cancer in age 59–74 years was elevated for individuals with high exposure to iron (OR 1.41, 95%CI 1.07–1.85), and high exposure to welding fumes (OR 1.43, 95%CI 1.09–1.89). Conclusions The only markedly elevated risks of kidney cancer were seen for the highest exposures of nickel and iron/welding fumes in specific age strata.
Databáze: OpenAIRE
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