Expression Patterns of the HIV Type 1 Coreceptors CCR5 and CXCR4 on CD4+T Cells and Monocytes from Cord and Adult Blood
Autor: | David D. Ho, Henry Pollack, Simon Monard, Hongmei Mo, Lijun Wu, William Borkowsky, Gemma Rochford, John P. Moore, James Ip, James A. Hoxie |
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Rok vydání: | 1998 |
Předmět: |
Adult
CD4-Positive T-Lymphocytes Receptors CXCR4 Chemokine Cellular immunity Cord Receptors CCR5 viruses Immunology Lymphocyte Activation CXCR4 Monocytes Virus Mice Virology medicine Animals Humans biology Monocyte virus diseases T lymphocyte Fetal Blood biology.organism_classification Infectious Diseases medicine.anatomical_structure Lentivirus HIV-1 biology.protein |
Zdroj: | AIDS Research and Human Retroviruses. 14:607-617 |
ISSN: | 1931-8405 0889-2229 |
Popis: | We have measured the surface expression of the HIV-1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood. The expression of CCR5 was largely restricted to the memory (CD45RAlow) subset, whereas CXCR4 was expressed on both memory and naive (CD45RAhigh) T cells. The paucity of memory CD4+ T cells in cord blood means that CCR5-positive cells are relatively uncommon, so the overall extent of CCR5 expression was reduced in cord blood, compared with adult blood. IL-2 activation of CD4+ T cells from both cord and adult bloods caused a substantial increase in CCR5 expression, but moderately decreased CXCR4 expression. PHA stimulation increased CCR5 expression slightly, but only on naive cells. Monocytes expressed both CCR5 and CXCR4 at levels that differed little between cord and adult blood. |
Databáze: | OpenAIRE |
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