Effect of HIV-1 and cytomegalovirus in bronchoalveolar lavage cells on the transfer factor for lung carbon monoxide in AIDS patients
Autor: | Fiona M. Moss, John Williamson, J Fleming, Katrina Donegan, D M Mitchell, R. B. Nieman, John R. Clarke |
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Rok vydání: | 1991 |
Předmět: |
Immunology
Congenital cytomegalovirus infection Cytomegalovirus Opportunistic Infections Polymerase Chain Reaction Pulmonary function testing DLCO Betaherpesvirinae medicine Immunology and Allergy Humans Lung Acquired Immunodeficiency Syndrome Carbon Monoxide medicine.diagnostic_test biology business.industry Pulmonary Gas Exchange Pneumonia Pneumocystis Respiratory disease virus diseases respiratory system biology.organism_classification medicine.disease respiratory tract diseases Infectious Diseases Bronchoalveolar lavage medicine.anatomical_structure HIV-1 Viral disease business Bronchoalveolar Lavage Fluid |
Zdroj: | AIDS (London, England). 5(11) |
ISSN: | 0269-9370 |
Popis: | Abnormalities in pulmonary function tests have been observed in AIDS patients with pulmonary disease. In this study, the polymerase chain reaction (PCR) was used to determine if the reductions in transfer factor for lung carbon monoxide (TLCO) were due to the presence of HIV-1 or cytomegalovirus (CMV). HIV-1 was detected in cells from bronchoalveolar lavage (BAL) in 35 out of 60 (58%) of patients. The detection of HIV-1 had no significant effect on pulmonary function. CMV was detected in the BAL of 58% of patients in this study but CMV was the sole viral pathogen in the lung of only two out of 60 (3.3%) individuals. A significant reduction in TLCO was observed in individuals with PCP where CMV was also detected in the BAL. This study shows that reduction in TLCO in HIV-seropositive patients is not due to the presence of HIV-1 or CMV alone in BAL cells. |
Databáze: | OpenAIRE |
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