Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
| Autor: | Michał Kunicki, Katarzyna Suchta, Anna Calik-Ksepka, Roman Smolarczyk, A. M. Duszewska, Katarzyna Smolarczyk, Ewa Rudnicka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Anti-Mullerian Hormone
medicine.medical_specialty endocrine system endocrine system diseases QH301-705.5 Review Catalysis Inorganic Chemistry Anovulation Pathogenesis hyperandrogenism Ovarian Follicle Internal medicine medicine AMH PCOS Endocrine system Humans Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Ultrasonography biology business.industry urogenital system Organic Chemistry Hyperandrogenism Anti-Müllerian hormone General Medicine medicine.disease Antral follicle Polycystic ovary female genital diseases and pregnancy complications Computer Science Applications Chemistry Endocrinology biology.protein Female business Hormone Polycystic Ovary Syndrome |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 12507, p 12507 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women. It is characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. PCOS is specified by an increased number of follicles at all growing stages, mainly seen in the preantral and small antral follicles and an increased serum level of Anti-Müllerian Hormone (AMH). Because of the strong correlation between circulating AMH levels and antral follicle count on ultrasound, Anti-Müllerian Hormone has been proposed as an alternative marker of ovulatory dysfunction in PCOS. However, the results from the current literature are not homogeneous, and the specific threshold of AMH in PCOS and PCOM is, therefore, very challenging. This review aims to update the current knowledge about AMH, the pathophysiology of AMH in the pathogenesis of PCOS, and the role of Anti-Müllerian Hormone in the treatment of this syndrome. |
| Databáze: | OpenAIRE |
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