A role for TLR10 in obesity and adipose tissue morphology

Autor: Rinke Stienstra, Marije Doppenberg-Oosting, Andreea Manuela Mirea, Inge C.L. van den Munckhof, Martin Jaeger, Leo A. B. Joosten, Anneke Hijmans, Lily Boutens, Mihai G. Netea
Rok vydání: 2018
Předmět:
Leptin
Male
0301 basic medicine
Biopsy
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Adipose tissue
Type 2 diabetes
Biochemistry
Cohort Studies
Voeding
Metabolisme en Genomica
chemistry.chemical_compound
0302 clinical medicine
Adipocyte
Adipocytes
Immunology and Allergy
Medicine
Gene Knock-In Techniques
Human Nutrition & Health
TLR10
Paraffin Embedding
Humane Voeding & Gezondheid
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
Hematology
Metabolism and Genomics
Up-Regulation
Metabolisme en Genomica
Nutrition
Metabolism and Genomics
Adiponectin
medicine.symptom
SNPs
medicine.medical_specialty
Immunology
Mice
Transgenic
030209 endocrinology & metabolism
Inflammation
Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9]
Polymorphism
Single Nucleotide
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Adipokines
Voeding
Internal medicine
Animals
Humans
Obesity
Molecular Biology
Nutrition
business.industry
Macrophages
medicine.disease
030104 developmental biology
Endocrinology
chemistry
Toll-Like Receptor 10
Metabolic syndrome
business
Zdroj: Cytokine, 108, pp. 205-212
Cytokine 108 (2018)
Cytokine, 108, 205-212
ISSN: 1043-4666
Popis: Toll like receptors (TLRs) are expressed in adipose tissue and promote adipose tissue inflammation during obesity. Recently, anti-inflammatory properties have been attributed to TLR10 in myeloid cells, the only member of the TLR family with inhibitory activity. In order to assess whether TLR10-induced inhibition of inflammation may be protective during the development of obesity and metabolic abnormalities we used transgenic human TLR10 mice (hTLR10tg) and wild type (WT) controls on a C57B6J background. HFD-feeding enhanced TLR10 expression in the adipose tissue, and HFD-fed hTLR10tg mice displayed reduced adipocyte size, adipose tissue weight, and a trend toward lower plasma insulin levels compared to WT mice. In humans, obese individuals with polymorphisms in the TLR10 gene displayed reduced macrophage infiltration in the adipose tissue accompanied by a trend to lower leptin levels and higher adiponectin levels in plasma. In healthy individuals with the same polymorphisms in the TLR10 gene we did not observe any difference in plasma concentrations of leptin and adiponectin. We conclude that TLR10 impacts adipose tissue morphology in obesity. Larger studies in humans are warranted to assess its potential value as therapeutic target in metabolic syndrome and type 2 diabetes.
Databáze: OpenAIRE
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