Upregulation of vasohibin-1 expression with angiogenesis and poor prognosis of hepatocellular carcinoma after curative surgery
| Autor: | Qiangxiu Wang, Chunqing Zhang, Xiangguo Tian, Qizhi Wang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Oncology Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Angiogenesis medicine.medical_treatment CD34 Cell Cycle Proteins Internal medicine medicine Humans Aged Proportional Hazards Models Vasohibin-1 Neovascularization Pathologic business.industry Liver Neoplasms Hematology General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Up-Regulation Angiogenesis inhibitor Vascular endothelial growth factor A Hepatocellular carcinoma Multivariate Analysis Immunohistochemistry Female Hepatectomy business |
| Zdroj: | Medical Oncology. 29:2727-2736 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-011-0106-7 |
| Popis: | Vasohibin-1 has recently been found and is known as an endogenous angiogenesis inhibitor, but the role of vasohibin-1 in hepatocellular carcinoma (HCC) is unknown. This study investigated the expression pattern of vasohibin-1, its correlation with clinicopathological features, and its potential role in tumor angiogenesis and prognosis of HCC. Expression of vasohibin-1, vascular endothelial growth factor-A (VEGF-A), and intratumoral microvessel density (MVD, labeled by CD34) were assessed by immunohistochemistry in 117 HCC specimens and adjacent nontumor liver tissues (ANLT). Correlation between vasohibin-1 and VEGF-A, MVD, and clinicopathological features was then investigated. Prognostic value of these factors was determined using Kaplan–Meier analysis and a Cox proportional hazards regression model. Cytoplasm high expression of vasohibin-1 was detected in 38.5% (45/117) of the HCC tissues, which was significantly higher than that in 16.2% (19/117) of ANLT (P < 0.001). Vasohibin-1 was statistically correlated with VEGF-A, MVD, and microvascular invasion in HCC (P = 0.014, 0.035, and 0.002, respectively). Patients with vasohibin-1 high expression had significantly poor disease-free survival (DFS) and overall survival (OS) at 5 years after curative hepatectomy (P < 0.001 for each). Multivariate analysis confirmed that vasohibin-1 high expression was an independent prognosticator for unfavorable DFS (HR = 2.554, P < 0.001) and OS (HR = 2.232, P = 0.002), along with VEGF-A and TNM stage. Upregulation of vasohibin-1 expression is associated with angiogenesis and poor prognosis of HCC. Vasohibin-1 and VEGF-A are the most important factors influencing the dismal prognosis based on the modulation of angiogenesis in HCC, which provides a rational approach for treatment in the future. |
| Databáze: | OpenAIRE |
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