Trimetrexate in malignant mesothelioma: A Cancer and Leukemia Group B Phase II study
| Autor: | M. R. Cooper, Karen H. Antman, Mark R. Green, Nicholas J. Vogelzang, James E. Herndon, Joseph M. Corson, L B Weissman |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Mesothelioma Cancer Research medicine.medical_specialty medicine.medical_treatment Phases of clinical research Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Hypoalbuminemia Aged Chemotherapy business.industry Cancer Middle Aged medicine.disease Survival Analysis Surgery Treatment Outcome Trimetrexate Oncology chemistry Toxicity Antifolate Female business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 12:1436-1442 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | PURPOSE Folic acid antagonists are reported to have activity against mesothelioma. The Cancer and Leukemia Group B (CALGB) undertook this phase II study of the new antifolate, trimetrexate (TMTX), to evaluate its response rate and toxicity in chemotherapy-naive patients with malignant mesothelioma. PATIENTS AND METHODS Fifty-two patients were accrued to this protocol. Because of concerns about TMTX toxicity in patients with malignant effusions and/or hypoalbuminemia, the first 17 patients were treated at a dose of 6 mg/m2 daily for 5 days every 21 days. Because minimal toxicity was observed, the subsequent 35 patients were treated at a dose of 10 mg/m2. RESULTS Two of 17 patients (12%) in the 6-mg/m2 treatment group had a partial response (PR) and four of 34 eligible patients (12%) in the 10-mg/m2 treatment group had a PR or regression (R) of assessable disease. No patient achieved a complete response (CR). Median survival durations were 5.0 and 8.9 months in the 6- and 10-mg/m2 treatment groups, respectively, while the 2-year survival rates were identical at 18%. At the 10-mg/m2 dose, toxicity was tolerable, with one toxic death from sepsis and a 12% rate of grade 4 thrombocytopenia and granulocytopenia. CONCLUSION In this large trial, TMTX showed minor activity in the treatment of malignant mesothelioma. Myelosuppression was mild and dose-related. Future studies of higher doses of TMTX should be considered. |
| Databáze: | OpenAIRE |
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