Reflections on the origins and evolution of genetic toxicology and the Environmental Mutagen Society
| Autor: | John S. Wassom, Heinrich V. Malling, K. Sankaranarayanan, Po-Yung Lu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Genetics
Societies Scientific medicine.medical_specialty Human environment Epidemiology Health Toxicology and Mutagenesis Public health Charter Environmental ethics Biology Environment History 20th Century Subspecialty History 21st Century medicine Quantitative assessment Humans Citation Molecular Biology Genetics (clinical) Genetic Toxicology Mutagens |
| Zdroj: | Environmental and molecular mutagenesis. 51(8-9) |
| ISSN: | 1098-2280 |
| Popis: | This article traces the development of the field of mutagenesis and its metamorphosis into the research area we now call genetic toxicology. In 1969, this transitional event led to the founding of the Environmental Mutagen Society (EMS). The charter of this new Society was to "encourage interest in and study of mutagens in the human environment, particularly as these may be of concern to public health." As the mutagenesis field unfolded and expanded, new wording appeared to better describe this evolving area of research. The term "genetic toxicology" was coined and became an important subspecialty of the broad area of toxicology. Genetic toxicology is now set for a thorough reappraisal of its methods, goals, and priorities to meet the challenges of the 21st Century. To better understand these challenges, we have revisited the primary goal that the EMS founders had in mind for the Society's main mission and objective, namely, the quantitative assessment of genetic (hereditary) risks to human populations exposed to environmental agents. We also have reflected upon some of the seminal events over the last 40 years that have influenced the advancement of the genetic toxicology discipline and the extent to which the Society's major goal and allied objectives have been achieved. Additionally, we have provided suggestions on how EMS can further advance the science of genetic toxicology in the postgenome era. Any oversight or failure to make proper acknowledgment of individuals, events, or the citation of relevant references in this article is unintentional. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text