Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects
| Autor: | Cornelis J. Stam, Edwin van Dellen, Frank P. Vleggaar, Tianne Numan, Paul van Vlieberghe, Arjen J. C. Slooter |
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| Přispěvatelé: | Anatomy and neurosciences, Neurology, Amsterdam Neuroscience - Brain Imaging, Clinical sciences, Neuroprotection & Neuromodulation |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Neurology Electroencephalography Midazolam/administration & dosage 0302 clinical medicine Brain Waves/drug effects Hypnotics and Sedatives/administration & dosage Neural Pathways Hypnotics and Sedatives Propofol/administration & dosage Brain/drug effects medicine.diagnostic_test Functional connectivity 05 social sciences Brain General Medicine midazolam Anesthesia Female medicine.symptom Propofol Neural Pathways/drug effects electroencephalography medicine.drug medicine.medical_specialty Midazolam Sedation Clinical Neurology Alpha (ethology) 050105 experimental psychology 03 medical and health sciences Journal Article medicine Humans 0501 psychology and cognitive sciences Neurology/Medicine Aged propofol business.industry functional connectivity Brain Waves minimum spanning tree (MST) Delirium Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Numan, T, van Dellen, E, Vleggaar, F P, van Vlieberghe, P, Stam, C J & Slooter, A J C 2019, ' Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects ', Clinical EEG and Neuroscience, vol. 50, no. 6, pp. 436-443 . https://doi.org/10.1177/1550059419838938 Clinical EEG and Neuroscience, 50(6), 436-443. SAGE Publications Inc. Clinical EEG and Neuroscience Clinical EEG and neuroscience, 50(6), 436. SAGE Publications Inc. |
| ISSN: | 1550-0594 |
| DOI: | 10.1177/1550059419838938 |
| Popis: | Background. Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects of light sedation with midazolam or propofol on a variety of EEG measures in older subjects. Methods. In patients (≥60 years without neuropsychiatric disease such as delirium), 2 EEG recordings were performed, before and after administration of either midazolam (n = 22) or propofol (n = 26) to facilitate an endoscopic procedure. Power spectrum, functional connectivity, and network topology based on the minimum spanning tree (MST) were compared within subjects. Results. Midazolam and propofol administration resulted in Richmond Agitation and Sedation Scale levels between 0 and −4 and between −2 and −4, respectively. Both agents altered the power spectra with increased delta (0.5-4 Hz) and decreased alpha (8-13 Hz) power. Only propofol was found to significantly reduce functional connectivity. In the beta frequency band, the MST was more integrated during midazolam sedation. Propofol sedation resulted in a less integrated network in the alpha frequency band. Conclusion. Despite the different levels of light sedation with midazolam and propofol, similar changes in power were found. Functional connectivity and network topology showed differences between midazolam and propofol sedation. Future research should establish if these differences are caused by the different levels of sedation or the mechanism of action of these agents. |
| Databáze: | OpenAIRE |
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