Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter
| Autor: | Patrick D. Bailey, David Meredith, C. A. Richard Boyd, Keith M. Morgan, Ian D. Collier, Rachel Pettecrew, Richard A. Price, George L. Kellett |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy Dipeptide Molecular Structure Stereochemistry Organic Chemistry Membrane Transport Proteins food and beverages Stereoisomerism Peptide Transporter Nuclear magnetic resonance spectroscopy Hydrogen-Ion Concentration Biochemistry chemistry.chemical_compound chemistry Molecule Sulfhydryl Compounds Proline Physical and Theoretical Chemistry Peptides Cis–trans isomerism |
| Zdroj: | Organic & Biomolecular Chemistry. 3:4038 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/b513274f |
| Popis: | The stereochemistry of thiodipeptides of proline [e.g. Ala-Psi[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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