Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase

Autor: Shi-feng Yun, Jiaxuan Li, Dandan Bu, Zesheng Xue, Qinghe Zeng, Wei Liu, Yu-ting Song, Meiqian Li, Jun Yan, Ruimin Huang, Tian Fang, Jiakuan Liu, Junzun Li, Yidan Zhang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Cholestenone 5 alpha-Reductase
030232 urology & nephrology
Prostatic Hyperplasia
lcsh:Medicine
Pharmacology
urologic and male genital diseases
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
5-alpha Reductase Inhibitors
Prostate
Testosterone
Receptor
lcsh:Science
Multidisciplinary
Hyperplasia
respiratory system
Spermatozoa
medicine.anatomical_structure
Receptors
Androgen
030220 oncology & carcinogenesis
Finasteride
congenital
hereditary
and neonatal diseases and abnormalities
Proliferative index
Urinary system
Down-Regulation
Article
03 medical and health sciences
medicine
Animals
Cell Proliferation
Benign prostatic hyperplasia
business.industry
Plant Extracts
lcsh:R
Epithelial Cells
Cell Cycle Checkpoints
Prostate-Specific Antigen
medicine.disease
respiratory tract diseases
Apocynaceae
Disease Models
Animal
SRD5A1
chemistry
bacteria
lcsh:Q
business
Carbolines
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-019-56145-z
Popis: Benign prostatic hyperplasia (BPH) is one of the most common diseases in the urinary system of elderly men. Pao extract is an herbal preparation of the bark of the Amazon rainforest tree Pao Pereira (Geissospermum vellosii), which was reported to inhibit prostate cancer cell proliferation. Herein we investigated the therapeutic potential of Pao extract against BPH development in a testosterone-induced BPH rat model. The administration of testosterone induced the prostate enlargement, compared with the sham operated group with vehicle treatment. The BPH/Pao group showed reduced prostate weight comparable with BPH/finasteride group. Notably, Pao treatment did not significantly reduce body weights and sperm number of rats, compared with the control group. Furthermore, Pao extract treatment reduced the proliferative index in prostate glands and testosterone-induced expression levels of AR, as well as androgen-associated proteins such as SRD5A1 and PSA. Moreover, Pao extract and its active component, flavopereirine, induced cytotoxicity on human prostate epithelial RWPE-1 cells in a dose- and time- dependent manner with G2/M arrest. Consistently, Pao extract and flavopereirine suppressed the expression levels of SRD5A1, AR and PSA, respectively. Together, these data demonstrated that Pao extract suppresses testosterone-induced BPH development through inhibiting AR activity and expression, and suggested that Pao extract may be a promising and relative safe agent for BPH.
Databáze: OpenAIRE
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