Expression of programmed death-ligand 1 (PD-L1) in human pituitary neuroendocrine tumor
| Autor: | Patrice Rodien, Alexandre Collin, Philippe Menei, Marie-Christine Rousselet, Claire Briet, Valentine Suteau |
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| Přispěvatelé: | Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty [SDV]Life Sciences [q-bio] medicine.medical_treatment Immunology Clone (cell biology) Neuroendocrine tumors B7-H1 Antigen 03 medical and health sciences 0302 clinical medicine PD-L1 Biomarkers Tumor Humans Immunology and Allergy Medicine Pituitary Neoplasms ComputingMilieux_MISCELLANEOUS Retrospective Studies biology business.industry Pituitary tumors Immunotherapy Middle Aged Prognosis medicine.disease 3. Good health Survival Rate Neuroendocrine Tumors Oncology biology.protein Immunohistochemistry Female Neoplasm Recurrence Local Antibody business Immunostaining Follow-Up Studies 030215 immunology |
| Zdroj: | Cancer Immunology, Immunotherapy Cancer Immunology, Immunotherapy, Springer Verlag, 2020, 69 (10), pp.2053-2061. ⟨10.1007/s00262-020-02611-x⟩ |
| ISSN: | 1432-0851 0340-7004 |
| Popis: | To explore the programmed death-ligand 1 (PD-L1) expression in varied subtypes of pituitary neuroendocrine tumors with assessment of their clinical behavior at diagnosis and follow-up. We conducted a retrospective monocentric study, including all patients operated in the Academic Hospital of Angers (France) for a pituitary neuroendocrine tumor between 2012 and 2018. PDL-1 immunostaining was performed using a European Conformity—In Vitro Diagnostic-labeled anti-PDL1 antibody (clone 22C3). PD-L1 immunostaining was evaluated as the percentage of tumor cells showing positive membrane staining, into four grades: grade 0 = |
| Databáze: | OpenAIRE |
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