Antifilarial activity of some 2H-1-benzopyran-2-ones (coumarins)
| Autor: | R. K. Chatterjee, P. K. Murthy, Rama Pati Tripathi, Som Nath Singh, Amiya P. Bhaduri, Renu Tripathi |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Mastomys coucha Veterinary (miscellaneous) Administration Oral Dipetalonema Filariasis chemistry.chemical_compound Ticks Coumarins Dipetalonema Infections medicine Animals Humans Anthelmintic Microfilariae Filarioidea Acanthocheilonema viteae biology Traditional medicine Anticoagulants Biological activity Sigmodon hispidus biology.organism_classification medicine.disease Coumarin Infectious Diseases chemistry Insect Science Injections Intravenous Immunology Female Parasitology medicine.drug |
| Zdroj: | Acta Tropica. 76:101-106 |
| ISSN: | 0001-706X |
| DOI: | 10.1016/s0001-706x(00)00070-x |
| Popis: | Six synthetic 2H-1-benzopyran-2-one (cournarin) derivatives (CDRI compounds # 1, 2, 3, 4, 5 and 6) were evaluated for filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae infections in cotton rats (Sigmodon hispidus) and Mastomys coucha respectively. Significant effects on macrofilariae (>80% death/sterilisation) were detected with compounds #2, 3 and 6 against L. carinii and/or A. viteae. Thus detection of filaricidal activity in benzopyrones, which are so far known for anti-inflammatory activity, provides a new lead for development of better filaricidal agents for combating filariasis. |
| Databáze: | OpenAIRE |
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