Sonothrombolysis in acute middle cerebral artery stroke
| Autor: | Mahmoud Haroun, Ahmed ElSadek, Azza Abdel Nasser, Samia Ashour, Ramez Reda Moustafa, Mohamed Hamdy Ibrahim, Amira Zaki Dwedar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Ultrasonography Doppler Transcranial Fibrinolytic Agents Internal medicine medicine.artery Occlusion medicine Humans In patient cardiovascular diseases Acute ischemic stroke Aged Aspirin business.industry Stroke scale Clinical course Infarction Middle Cerebral Artery Middle Aged Surgery Stroke Treatment Outcome Neurology Middle cerebral artery cardiovascular system Cardiology Female Neurology (clinical) Middle cerebral artery stroke business Blood Flow Velocity medicine.drug |
| Zdroj: | Neurology India. 62(1) |
| ISSN: | 0028-3886 |
| Popis: | Objectives: The objective of the following study is to determine the effect of continuous insonation using 2-MHz transcranial Doppler-ultrasound (TCD-US) on the recanalization rate and the short-term outcome in subjects with acute ischemic stroke due to middle cerebral artery (MCA) occlusion. Materials and Methods: A total of 42 patients with acute ischemic stroke due to MCA occlusion within 24 h were recruited and randomly allotted to two groups (21 patients in each group). Group 1 included patients who received 1 h continuous TCD-US for MCA and Group 2 included patients who did not receive 1 h continuous TCD-US. Patients in both groups were received MCA insonation and TCD study to measure mean flow velocity (MFV) in MCA one after the initial study at 20 and 60 min. All patients received aspirin (150-325 mg). The clinical course during hospital stay was assessed before and after 1 h of US insonation, at 24 h after symptom onset using the National Institutes of Health Stroke Scale. Results: Change in MFV after insonation for Group 1 in comparison to Group 2 at 3 time points was significantly high (P < 0.001). Conclusion: Sonothrombolysis is a therapeutic option to improve the outcomes in patients with acute ischemic stroke due to MCA occlusion. |
| Databáze: | OpenAIRE |
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