Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study
| Autor: | Igor P. Pogribny, Nigel J. Walker, Frederick A. Beland, Daniel R. Doerge, Linda S. Von Tungeln, Greg R. Olson, M. Matilde Marques, Robert P. Felton, Maria C.B. Mendoza, Brett T. Thorn |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Physiology 010501 environmental sciences Toxicology 01 natural sciences Article Lesion 03 medical and health sciences chemistry.chemical_compound Mice Furan medicine Bioassay Animals Furans Carcinogen 0105 earth and related environmental sciences Dose-Response Relationship Drug Chemistry Body Weight General Medicine Neoplasms Experimental Organ Size Hyperplasia Epididymis medicine.disease Rats Inbred F344 Rats Basophilic 030104 developmental biology medicine.anatomical_structure Biochemistry Biliary tract Carcinogens medicine.symptom Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 99 |
| ISSN: | 1873-6351 |
| Popis: | Furan is a volatile organic chemical that is a contaminant in many common foods. Furan is hepatocarcinogenic in mice and rats; however, the risk to humans from dietary exposure to furan cannot be estimated accurately because the lowest tested dose of furan in a 2-year bioassay in rats gave nearly a 100% incidence of cholangiocarcinoma. To provide bioassay data that can be used in preparing risk assessments, the carcinogenicity of furan was determined in male F344/N Nctr rats administered 0, 0.02, 0.044, 0.092, 0.2, 0.44, 0.92, and 2 mg furan/kg body weight (BW) by gavage 5 days/week for 2 years. Exposure to furan was associated with the development of malignant mesothelioma on membranes surrounding the epididymis and on the testicular tunics, with the increase being significant at 2 mg furan/kg BW. There was also a dose-related increase in the incidence of mononuclear cell leukemia, with the increase in incidence being significant at 0.092, 0.2, 0.92, and 2 mg furan/kg BW. Dose-related non-neoplastic liver lesions included cholangiofibrosis, mixed cell foci, basophilic foci, biliary tract hyperplasia, oval cell hyperplasia, regenerative hyperplasia, and cytoplasmic vacuolization. The most sensitive non-neoplastic lesion was cholangiofibrosis, the frequency of which increased significantly at 0.2 mg furan/kg BW. |
| Databáze: | OpenAIRE |
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