Insights on the Genotype Distribution Among Cryptococcus neoformans and C. gattii Portuguese Clinical Isolates
| Autor: | Kamal Mansinho, Wieland Meyer, Inês Silva, Fernando Sérgio Rodrigues Ribeiro Teles, João Inácio, Ana Paula Maduro, Maria da Luz Martins |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Genotype Applied Microbiology and Biotechnology Microbiology Young Adult medicine Humans Historical record Aged Cryptococcus neoformans AIDS-Related Opportunistic Infections biology Cryptococcosis General Medicine Middle Aged biology.organism_classification medicine.disease language.human_language Molecular Typing Cryptococcus language Female Portuguese |
| Zdroj: | Current Microbiology. 68:199-203 |
| ISSN: | 1432-0991 0343-8651 |
| DOI: | 10.1007/s00284-013-0452-0 |
| Popis: | This study provides a comprehensive picture of the C. neoformans/C. gattii molecular types most often associated with human cryptococcosis in Portugal and assesses the impact of C. gattii in these infections. One hundred and twenty-two clinical isolates, from distinct patients, were identified as C. neoformans and genotyped by URA5-RFLP, with the molecular types VNI (45.5 %) and VNIII (30.9 %) being the most commonly found ones. The molecular types VNII (11.4 %) and VNIV (11.4 %) were less abundant. One patient was found to be infected with a VGII isolate. This patient exhibited unusual clinical symptoms of cryptococcosis, reinforcing the suspicion for the presence of a different genotypic pattern, as determined afterwards. This case was detected in 2007 and is the first report of a potential autochthonous C. gattii infection case in Portugal, as the patient revealed no historical record of travelling outside the country. |
| Databáze: | OpenAIRE |
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