Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice
| Autor: | I. Pénzes, Sára Tóth, Peter Csermely |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Aging
Cytoplasm medicine.medical_specialty T-Lymphocytes chemistry.chemical_element Calcium Lymphocyte Activation Calcium in biology Mice Cellular and Molecular Neuroscience Immune system Internal medicine medicine Animals Molecular Biology Pharmacology Calcium metabolism business.industry Cell Biology Overcrowding T-lymphocyte activation Cytoplasmic free calcium Crowding Endocrinology chemistry Mice Inbred CBA Molecular Medicine business Homeostasis |
| Zdroj: | Experientia. 51:976-979 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01921751 |
| Popis: | Intracellular calcium concentration is a sensitive marker of the homeostasis of living cells, and its increase is an essential step of T lymphocyte activation. Changes in the environment provoke an adaptive stress-response of the organism. In our present work we have investigated the effect of chronic overcrowding on resting and lectin-stimulated cytoplasmic free calcium concentration of splenic T lymphocytes from young and aged CBA/CA mice (50 animals total). The animals were kept under ‘normal’ (68 cm2/animal) or ‘overcrowded’ (22 cm2/animal) conditions for 3 months. Young animals showed no change in resting and stimulated calcium after overcrowding. T cells from aged mice, however, displayed significantly smaller levels of both resting and lectin-stimulated intracellular calcium concentration (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink