Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones

Autor:	D. J. Wendt, Augustus O. Grant
Rok vydání:	1992
Předmět:	Pharmacology Neurotransmitter Agents Chemistry Myocardium Sodium channel Heart Toxicology Binding Competitive Hormones Sodium Channels Structure-Activity Relationship Mechanism of action Drug development medicine Animals Channel blocker medicine.symptom Anti-Arrhythmia Agents Hormone
Zdroj:	Trends in Pharmacological Sciences. 13:352-358
ISSN:	0165-6147
DOI:	10.1016/0165-6147(92)90108-i
Popis:	The Na+ channel is an important target for the action of antiarrhythmic drugs. Application of contemporary biophysical, biochemical and molecular biological techniques have added considerably to our knowledge of its structure, function, modulation and block by antiarrhythmic drugs. The increased mortality from the use of these drugs for prophylaxis of cardiac arrhythmias has forced a re-evaluation of their use and of the entire pharmacological strategy of arrhythmia management. Gus Grant and David Wendt review recent studies on the block and modulation of cardiac Na+ channels and the place of Na+ channel blockers in future antiarrhythmic drug development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0348b6b526b586e412174ecadd7b9a4 https://doi.org/10.1016/0165-6147(92)90108-i Zobrazit plný text záznamu